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KMID : 1001920110490060323
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Journal of Korean Neurosurgical Society
2011 Volume.49 No. 6 p.323 ~ p.328
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Effect of Amniotic Membrane to Reduce Postlaminectomy Epidural Adhesion on a Rat Model
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Choi Hyu-Jin
Kim Kyoung-Beom
Kwon Young-Min
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Abstract
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Objective : Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model.
Methods : A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks.
Results : The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B.
Conclusion : This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
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KEYWORD
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Human amniotic membrane, Failed back surgery syndrome, Epidural adhesion, Laminectomy
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